This two-part post was written and published with the sole intent to dissolve any doubts regarding the sufficiency of the amount of research material presently available on ozone therapy. Plenty of research has been done, especially in the last 25-year period, in the course of which the world has seen more virulent viruses emerge almost in regular intervals – as well as mutations of existing viruses. Naturally, much more research could have been completed, as the motivation for it clearly existed, were it not for the forces motivated to sabotage any such attempts, especially in the English- speaking world. 
This does not change one iota of the truth that by now, we basically know how ozone works, why it works – and why for some pathologies it is such effective medicine. Many good things in this world are open secrets, even if only relatively few people know about them. The clinical and therapeutic effects of ozone are among these. The ignorance of the many does not prove the proven insights of the few wrong.So, now lets get back to Oleg Maslennikov’s, Claudia Kontorshchikova’s and Irina Gribkova’s wonderful ‘Ozone Health Manual’, 39-pages short, but filled with very valuable and condensed research information. Besides the list of four effects mentioned in Part I of our post, ozone has four additional clinical effects. They are:
· “Activation of oxygen-dependent physiological processes – Ozone doses, however low they are, cause an increase in free and dissolved blood oxygen, with rapid intensification of enzymes that catalyze aerobic oxidation of carbohydrates, lipids and proteins, with formation of ATP energy substrate. Of great significance in this, is the mitochodrian activation of H-ATP-ase, responsible for conjugation of respiratory processes and oxidative phosphorylation resulting in ATP-synthesis.
· Optimization of pro- and anti-oxidant systems – This is regarded as one of the main effects of systemic ozone therapy. It happens through ozone’s impact on cell membranes and bringing to balance the levels f lipid per-oxidation products and of the antioxidant defense system. In response to ozone, there occurs the compensatory increase in the activity of antioxidant enzymes-superoxidismutase (SOD), catalase and glutathio-peroxidase. Due to restored aerobic metabolic reactions there is the accumulation of NADH2 and NADH2_ , which function as proton donors to restore the oxidized components of the non-enzymic antioxidant system (glutathione, vitamin E, ascorbic acid etc). The use of exogenic antioxidants with preliminary calculated dosage is obligatory when high ozone concentrations are used.
· Haemostatic effect – Which is dosage dependent. High concentrations administered for external use cause evident hyper coagulation, while parenteral administration of low concentrations is characterized by the decrease in thrombocytic and coagulative levels of hemostasis, as well as by an increase in fibrinilytic activity.
· Immune Modulation – Which is based on ozone’s interaction with lipid structures of cell membranes, and depends on the dose administered. – Low ozone concentrations promote the accumulation of ozonides on the membranes of phagocytic cells – monocytes and macrophages. Due to ozonides, these cells then stimulate the cytokines synthesis of different classes. Cytokines being biologically active peptides, contribute to the further activation of the non-specific defense system (rise in body temperature, generation of acute-phase peptides in the liver0, and, apart for this, they also activate cellular and humeral immunity. Together, they facilitate the treatment of secondary immune-deficiency. – High ozone concentrations aggravate the processes of lipid per-oxidation in the cell membranes of the same phagocytic cells, with the accumulation of the toxic and hard products of lipid per-oxitation (malon de-aldehyde and Shiff bases), which inhibit cytokines synthesis, and thus prevent the activation of T-helpers, lymphocytes, aimed at regulating immune globulin generation by B-lymphocytes. The effects of high concentration are thus put to use in the treatment of patients with auto-immune pathologies such as rheumatoid disease, disseminated sclerosis and sclerodermia…”
We apologize for the ‘medical Chinese’ (or should we say ‘Russian’) in which most of the presentation is written. However, it seemed important to also include the background information on why ozone exhibits virucidal, analgesic, or anti-inflammatory properties. Lists of its therapeutic effects have been published before. But in themselves these lists are not convincing to the educated reader. With the background information, they may be.