It does not come as a surprise that one of the most concise, informative, readable and reader friendly (for the lay reader as well as for the medically trained) monographies on Coenzyme Q10, was put together by a clinical cardiologist. He describes the countless merits mentions the many studies that have yielded positive results for the treatment with Q 10, but also doesn’t fail to point to cases when the test results were neutral or negative. The book is The Coenzyme Q 10 Phenomenon. Stephen T. Sinatra M.D. F.A. C.C. is its author.Get a copy of the book, if you want to learn it all and in a nutshell (with extensive footnotes and quotations as leads for further study). Here, we can only quote the overview from the section on clinical cardiovascular disease. Another reason for this posting is the fact that “Co-Enzyme Q10 (CoQ10) in the Treatment of Cardiovascular Disease” of June 13th, 2011, so far is the most popular and most widely read post in the Healthy Healing Center Goa Blog. People really seem to want to know more. http://healthyhealingcentergoa.blogspot.com/2011/06/co-enzyme-q10-coq10-in-treatment-of.html
“A deficiency of Coenzyme Q10 is quite common in cardiac patients. This has been well documented in myocardial biopsies, especially in patients undergoing cardiac transplantation. Researchers found the lowest tissue levels of CoQ10 in the most sick and compromised patients. Most of them were, in fact, what we call class IV cardiac patients, those who have symptoms (extreme fatigue, chest discomfort or shortness of breath) even when they are just resting.”
“Because the heart is so metabolically active and requires a constant supply of ATP for continued pulsation, it is especially vulnerable to CoQ10 deficiencies. Fortunately, however, the heart muscle is also the most responsive tissue in the body to CoQ10 supplementation, rendering Q10 a nutrient with great promise for the treatment of cardiovascular disease.”
“CoQ10 deficiencies have been confirmed in patients with congestive heart failure, coronary artery disease, angina pectoris, cardiomyopathy, hypertension, mitral valve prolapse and even in those following coronary bypass surgery. In fact, the literature so well documents both CoQ10 deficiencies and response to supplementation for heart disease that in 1992 I asked the chief of pharmacy at my hospital to place CoQ10 on hospital formulary.”
“Coenzyme Q10 can be administered in a wide variety of clinical settings. Although clinical research has consistently shown that Coenzyme Q10 is clinically effective for coronary artery disease, arrhythmia, high blood pressure, as well as the cardio-toxic side effects of adriamycin treatment (a form of chemotherapy) over the past two decades many clinical investigations on Coenzyme Q10 have focused on congestive heart failure and cardiomyopathy.”
“A strong correlation between low blood and tissue levels of Coenzyme Q10 and the severity of heart failure has been consistently confirmed. Experimental and clinical data have provided extensive evidence that CoQ10 supplementation in patients with cardiomyopathy and congestive heart failure has resulted in improvements of multiple indicators of the heart’s pumping ability, including left ventricular function, ejection fraction, exercise tolerance, diastolic dysfunction, clinical outcome and quality of life.”